Study proves that bilateral premenopausal oophorectomy is associated with cognitive impairment

Ovariectomy is a surgical procedure and when it involves removal of both ovaries, it is called bilateral oophorectomy.

The researchers argue that the results of this research argue that they are beneficial for patients with ovarian cancer.

Research has found that patients who had their ovaries surgically removed before the age of 46 were more likely to be infected Deterioration Mild cognitive impairment after about 30 years, compared to a sample that did not undergo this type of intervention.

It was a cross-sectional study with cases and controls that used data from the Mayo Clinic Study on Aging (MCSA), which contains data from a prospective population study that examined risk factors, prevalence and incidences of cognitive impairment — including mild — A representative sample of women in the United States.

Specifically, the sample included 2,732 women – mostly white – aged 50 to 89 who participated in the MCSA study from 2004 to 2019, who underwent a clinical assessment and about nine tests covering four cognitive areas. Almost all participants (98.4%) were white.

On clinical evaluation, 283 women (10.4%) were diagnosed with mild cognitive impairment.

Epidemiological data in turn support that a total of 625 women (22.9%) had a history of bilateral oophorectomy.

Within this same group, about 161 women underwent the procedure before age 46 and before menopause, with 46 (28.6%) receiving oral conjugated estrogen – a mixture of estrogen hormones – while the remaining 95 (59.0%) did not receive estrogen therapy.

The study found that, compared to women who did not have a bilateral oophorectomy, those who had an oophorectomy before the age of 46 had a statistically greater chance of developing mild cognitive impairment, moreover, it ensures that evidence has been found that treatment with estrogen He was. commitment to Less risk of deterioration perceptual Moderate among younger women 46 years old.

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The study authors emphasize that this type of procedure is frequently used in countries due to the fact that hormonal surge Associated with ovarian function and its potential negative long-term impact, clinicians must consider and weigh the risks of this surgery against its benefits.

Additionally, they argue that the results of this research argue that they are beneficial for Ovarian Cancer Patients To measure the risks and benefits of premenopausal surgery as a preventative measure for ovarian cancer.

access to study Here.