Increased detection of variant cases in UK and Manaus in the country – Telam

Four variants have been discovered in the country: those of the United Kingdom, Manaus, California and Rio de Janeiro.

Coronavirus variants from the United Kingdom and Manaus have recorded an increase in the frequency of case detection across the country, according to the latest report from PAIS Project on SARS-CoV-2 Variable Monitoring of the nation’s Ministry of Science, Technology and Innovation.

The study included A total of 1,848 samples from CABA and the provinces of Buenos Aires, Cordoba, Neuqun, Santa Fe, Ro Negro, Mendoza, San Luis and Entre Ros, Showed that there was an increase in the frequency of detection of the variants 501Y.V1 (UK), 501Y.V3 (P.1, Manaus) and the L452Q mutation without an epidemiological association with overseas tourism between early March and late March. From April.

In AMBA, there was a frequency of 27.1% (CABA) and 12.8% (GBA) for the UK variant; 31.3% (CABA) and 31.9% (GBA) for the 501Y.V3 variant for Manaus; And 33.3% (CABA) and 48.9% (GBA) for the L452Q mutation aligned with the C.37 lineage.

To date, the set of mutations characteristic of the South African variant has not been revealed.

By mid-April, more than 90% of SARS-CoV-2 viruses that circulated in AMBA had mutations in the spike protein that distinguished them from viruses that circulated in the first wave.

The report highlights that L.The Manaus variant was detected in the greater La Plata region in 70.7% of the cases analyzed, while in Mar del Plata it had 42.9% of the infections.The city of Tandil presented 62.5% of cases associated with the UK variant.

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For this part, In San Luis the Manaus variant was detected in 46.6%; In entry Ross, a predominance of this variable was also observed, in 58.3% of cases, in individuals with no history of foreign travel or an epidemiological link to travelers.

In General Alvear, County of Mendoza, all the cases analyzed correspond to the Manaus variable, Although “this outbreak is linked to the return of a local tourist group,” it has been identified.

In turn, in the province Santa Fe Two cases of variant 501Y.V3 (Manaus) and one case of variant 501Y.V1 (UK) were detected in individuals with no history of overseas travel or close contact with travelers.

On Cordoba Two cases of the 501Y.V3 variant (P.1, Manaus) were detected in individuals with a travel history and seven cases of the 501Y.V1 variant (UK), two of them with a travel history to Mexico and five acquired in social media.

Finally, in the province of Newton The state of the variable 501Y.V3 (Manaus) was detected in a temporary local factor.

Active monitoring of SARS-CoV-2 variants was performed Four variables are allowed to be specified Global epidemiological concern in our country: Variant 501Y.V1 (UK), variant 501Y.V3 (lineage P.1, Manaus), variant P.2 (Rio de Janeiro) and variant CAL.20C (California, lineages B 1.427 and B 1429)It allowed the discovery of a strain of increasing regional importance, the lineage C.37.

The PAIS Project was established by the nation’s Ministry of Science, Technology and Innovation, and the Inter-Institutional Consortium for Genome Sequencing and Genomic Studies of SARS-CoV-2.

It is made up of research groups from different institutions with the aim of determining genome sequences and performing other genomic studies for SARS-CoV-2.

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Coordinated by Dr Mariana Vegas from Ricardo Gutierrez Children’s Hospital Virology Lab, the team works jointly and collaboratively to conduct genomic studies of SARS-CoV-2 in our country and contribute to local knowledge and global database of the GISAID viral cycle (Global Initiative to Share All Influenza Data).

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