A group of Spanish researchers has improved the condition of a patient with a type of epidermolysis bullosa with muscular dystrophy.
Blisters can appear in response to a minor injury, including heat, rubbing, or scratching. Photo: shutterstock.
Epidermal necrolysis refers to a number of rare diseases that cause symptomsone casean fur crisp, with blisters. can even appear Against heat, friction or scratchingIt can also appear inside the body, such as the mouth or stomach.
Most of the time, epidermal necrolysis It is hereditary and manifests itself in childhood or the first years of lifeHowever, there are those who show the first symptoms in their teens or early adulthood.
Although there is no cure for epidermolysis, mild manifestations may improve with age. Treatment focuses on taking care of existing pimples Preventing the possibility of a new outbreak blisters.
Symptoms can vary, but are generally characterized by a fur fragile with blistersthick or not forming nails, blisters in the throat or inside the mouth, Thickening of the skin on the palms of the hands or soles of the feetAnd blisters on the scalp fur Too thin, dental problems, difficulty swallowing, itching and pain in the fur.
in it studyresearchers from the Research Chair of the Carlos III University of Madrid, Center for Research in Energy, Environment and Technological Research, among others, participated.
Epidermolysis bullosa, with muscular dystrophy, is a Disorder caused by mutations in the pectin genetherefore, in addition to fragility in furAnd Patients develop progressive weakness of the skeletal muscles and respiratory system, negatively affecting their quality of life, leading to increased morbidity and mortality.
In advanced work The use of gentamicin as a compound has been evaluated, able to suppress the consequences of mutations. Researcher Maria José Escamez coordinated a group of primary and clinical researchers who made the treatment of this condition possible.
The work reported the efficacy of gentamicin at the time of achieving a large production of pectin in cells of furAnd what is more, Increased levels of pectin in the skin were obtained A slight improvement in double muscles The skeleton and respiratory system.
Escamez stated, “This study reveals the potential value of gentamicin as a treatment for epidermolysis bullosa.”